Longitudinal Analysis of Natural Killer Cells in Dengue Virus-Infected Patients in Comparison to Chikungunya and Chikungunya/Dengue Virus-Infected Patients.

Date publication

mars 2016

Journal

PLoS neglected tropical diseases

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DEVILLIERS Hervé

Tous les auteurs :
Petitdemange C, Wauquier N, Devilliers H, Yssel H, Mombo I, Caron M, Nkoghé D, Debré P, Leroy E, Vieillard V

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26938618

Résumé

Dengue virus (DENV) is the most prominent arbovirus worldwide, causing major epidemics in South-East Asia, South America and Africa. In 2010, a major DENV-2 outbreak occurred in Gabon with cases of patients co-infected with chikungunya virus (CHIKV). Although the innate immune response is thought to be of primordial importance in the development and outcome of arbovirus-associated pathologies, our knowledge of the role of natural killer (NK) cells during DENV-2 infection is in its infancy.

Mots clés

Adult, Chikungunya Fever, complications, Coinfection, pathology, Dengue, complications, Female, Gabon, Humans, Killer Cells, Natural, immunology, Longitudinal Studies, Male

Référence

PLoS Negl Trop Dis. 2016 Mar;10(3):e0004499