Trichodysplasia spinulosa: a polyomavirus infection specifically targeting follicular keratinocytes in immunocompromised patients.

Date publication

mars 2016

Journal

The British journal of dermatology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr AUBIN François

Tous les auteurs :
Rouanet J, Aubin F, Gaboriaud P, Berthon P, Feltkamp MC, Bessenay L, Touzé A, Nicol JT, Franck F, D'Incan M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26663358

Résumé

Trichodysplasia spinulosa (TS) is a rare skin disease, caused by a specific polyomavirus, occurring in immunocompromised patients. The pathophysiological mechanisms of TS are not yet fully understood. By using polymerase chain reaction and skin biopsy immunostaining we report evidence, in a paediatric case, of follicular keratinocytes being the primary target of trichodysplasia spinulosa-associated polyomavirus.

Mots clés

Child, Hair Diseases, pathology, Hair Follicle, pathology, Humans, Immunocompromised Host, Immunosuppressive Agents, adverse effects, Keratinocytes, virology, Male, Opportunistic Infections, complications, Polyomavirus Infections, complications, Skin Diseases, Viral, complications

Référence

Br. J. Dermatol.. 2016 Mar;174(3):629-32