IL-33/ST2 pathway regulates neutrophil migration and predicts outcome in patients with severe alcoholic hepatitis.

Date publication

janvier 2020

Journal

Journal of hepatology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr PAIS DE BARROS Jean-Paul

Tous les auteurs :
Artru F, Saleh MB, Maggiotto F, Lassailly G, Ningarhari M, Demaret J, Ntandja-Wandji LC, Pais de Barros JP, Labreuche J, Drumez E, Helou DG, Dharancy S, Gantier E, Périanin A, Chollet-Martin S, Bataller R, Mathurin P, Dubuquoy L, Louvet A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/31953139

Résumé

Severe alcoholic hepatitis (SAH) is associated with a high risk of infection. The interleukin-33 (IL33)/ST2 pathway is involved in sepsis control but data in alcohol-related liver disease (ALD) are lacking. We aimed to characterize the role of IL-33/ST2 in the neutrophils (PMNs) of patients with ALD and SAH.

Mots clés

Alcoholic hepatitis, IL-33, Interleukin-33, cirrhosis, corticosteroids, infection, migration, neutrophils, polymorphonuclear neutrophils

Référence

J. Hepatol.. 2020 Jan 14;: