Human skin penetration of hyaluronic acid of different molecular weights as probed by Raman spectroscopy.

Date publication

février 2016

Journal

Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GOBINET Cyril , Pr PIOT Olivier

Tous les auteurs :
Essendoubi M, Gobinet C, Reynaud R, Angiboust JF, Manfait M, Piot O

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25877232

Résumé

Topical delivery of molecules into the human skin is one of the main issues in dermatology and cosmetology. Several techniques were developed to study molecules penetration into the human skin. Although widely accepted, the conventional methods such as Franz diffusion cells are unable to provide the accurate localization of actives in the skin layers. A different approach based on Raman spectroscopy has been proposed to follow-up the permeation of actives. It presents a high molecular specificity to distinguish exogenous molecules from skin constituents.

Mots clés

Administration, Cutaneous, Adult, Female, Humans, Hyaluronic Acid, administration & dosage, In Vitro Techniques, Molecular Weight, Skin, chemistry, Skin Absorption, physiology, Spectrum Analysis, Raman, methods, Structure-Activity Relationship

Référence

Skin Res Technol. 2016 Feb;22(1):55-62