"Immunonutrition" Has Failed to Improve Peritonitis-Induced Septic Shock in Rodents.

Date publication

janvier 2016

Journal

PloS one

Auteurs

Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie

Tous les auteurs :
Boisramé-Helms J, Meyer G, Degirmenci SE, Burban M, Schini-Kerth V, Cynober L, De Bandt JP, Hasselmann M, Meziani F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26808822

Résumé

Immunonutrition in sepsis, including n-3 poly-unsaturated fatty acids (PUFAs) or L-arginine supplementation, is a controversial issue that has yielded a great number of studies for the last thirty-five years, and the conclusions regarding the quantity and quality of this support in patients are deceiving. The aim of the present experimental study is to investigate the effects of a pretreatment with enteral nutrition enriched with n-3 PUFAs or L-arginine on vascular dysfunctions, inflammation and oxidative stress during septic shock in rats.

Mots clés

Animals, Arginine, therapeutic use, Fatty Acids, Omega-3, therapeutic use, Male, Peritonitis, drug therapy, Rats, Rats, Wistar, Sepsis, drug therapy, Shock, Septic, drug therapy

Référence

PLoS ONE. 2016 ;11(1):e0147644