Flavaglines Ameliorate Experimental Colitis and Protect Against Intestinal Epithelial Cell Apoptosis and Mitochondrial Dysfunction.

Date publication

janvier 2016

Journal

Inflammatory bowel diseases

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DESAUBRY Laurent

Tous les auteurs :
Han J, Zhao Q, Basmadjian C, Désaubry L, Theiss AL

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26398710

Résumé

Flavaglines are a family of natural compounds shown to have anti-inflammatory and cytoprotective effects in neurons and cardiomyocytes. Flavaglines target prohibitins as ligands, which are scaffold proteins that regulate mitochondrial function, cell survival, and transcription. This study tested the therapeutic potential of flavaglines to promote intestinal epithelial cell homeostasis and to protect against a model of experimental colitis in which inflammation is driven by epithelial ulceration.

Mots clés

Animals, Apoptosis, drug effects, Benzofurans, pharmacology, Biological Products, pharmacology, Caco-2 Cells, Colitis, chemically induced, Cytokines, metabolism, Dextran Sulfate, toxicity, Epithelial Cells, drug effects, Female, Humans, Inflammation Mediators, metabolism, Intestinal Mucosa, drug effects, Intestines, drug effects, Male, Mice, Mice, Inbred C57BL, Mitochondria, drug effects, Reactive Oxygen Species, metabolism

Référence

Inflamm. Bowel Dis.. 2016 Jan;22(1):55-67