Lumican Inhibits SNAIL-Induced Melanoma Cell Migration Specifically by Blocking MMP-14 Activity.

Date publication

janvier 2016

Journal

PloS one

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BREZILLON Stéphane

Tous les auteurs :
Stasiak M, Boncela J, Perreau C, Karamanou K, Chatron-Colliet A, Proult I, Przygodzka P, Chakravarti S, Maquart FX, Kowalska MA, Wegrowski Y, Brézillon S

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26930497

Résumé

Lumican, a small leucine rich proteoglycan, inhibits MMP-14 activity and melanoma cell migration in vitro and in vivo. Snail triggers epithelial-mesenchymal transitions endowing epithelial cells with migratory and invasive properties during tumor progression. The aim of this work was to investigate lumican effects on MMP-14 activity and migration of Snail overexpressing B16F1 (Snail-B16F1) melanoma cells and HT-29 colon adenocarcinoma cells. Lumican inhibits the Snail induced MMP-14 activity in B16F1 but not in HT-29 cells. In Snail-B16F1 cells, lumican inhibits migration, growth, and melanoma primary tumor development. A lumican-based strategy targeting Snail-induced MMP-14 activity might be useful for melanoma treatment.

Mots clés

Cell Line, Tumor, Cell Movement, drug effects, Chondroitin Sulfate Proteoglycans, pharmacology, HT29 Cells, Humans, Keratan Sulfate, pharmacology, Lumican, Matrix Metalloproteinase 14, metabolism, Melanoma, metabolism, Snail Family Transcription Factors, Transcription Factors, metabolism

Référence

PLoS ONE. 2016 ;11(3):e0150226