Anti-Saccharomyces cerevisiae Immunogloblin G and Immunoglobulin A antibodies are associated with systemic inflammation and advanced disease in hidradenitis suppurativa.

Fiche publication

Date publication

février 2020

Journal

The Journal of allergy and clinical immunology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr AUBIN François

Tous les auteurs :
Assan F, Gottlieb J, Tubach F, Lebbah S, Guigue N, Hickman G, Pape E, Madrange M, Delaporte E, Sendid B, Aubin F, Derouin F, Bretagne S, Richette P, Smahi A, Sbidian E, Bachelez H

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32061710

Résumé

This is the first prospective study showing that ASCA are biomarkers for HS, especially in severe inflammatory forms, but not in PV, supporting the contribution of a gut fungal dysbiosis to HS pathogenesis.