Medicarpin and millepurpan, two flavonoids isolated from Medicago sativa, induce apoptosis and overcome multidrug resistance in leukemia P388 cells.

Date publication

décembre 2015

Journal

Phytomedicine : international journal of phytotherapy and phytopharmacology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MORJANI Hamid , Dr EL BTAOURI Hassan

Tous les auteurs :
Gatouillat G, Magid AA, Bertin E, El btaouri H, Morjani H, Lavaud C, Madoulet C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26598918

Résumé

High consumption of flavonoids has been associated with a decrease risk of cancer. Alfalfa (Medicago sativa) leaves have been widely used in traditional medicine and is currently used as a dietary supplement because of their high nutrient content. We previously reported the cytotoxic activity of alfalfa leaf extracts against several sensitive and multidrug resistant tumor cell lines.

Mots clés

Animals, Apoptosis, drug effects, Caspases, metabolism, Cell Line, Tumor, drug effects, Doxorubicin, Drug Resistance, Multiple, drug effects, Drug Resistance, Neoplasm, drug effects, Flavonoids, pharmacology, Leukemia P388, metabolism, Medicago sativa, chemistry, Mice, Molecular Structure, P-Glycoprotein, metabolism, Plant Leaves, chemistry, Pterocarpans, pharmacology

Référence

Phytomedicine. 2015 Dec;22(13):1186-94