Glycosyl phosphatidylinositol (GPI)/inositolphosphate glycan (IPG): an intracellular signalling system involved in the control of thyroid cell proliferation.

Date publication

décembre 1998

Journal

Biochimie

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MARTINY Laurent , Dr EL BTAOURI Hassan

Tous les auteurs :
Petitfrere E, Sartelet H, Vivien D, Varela-Nieto I, Elbtaouri H, Martiny L, Haye B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/9924986

Résumé

In porcine thyrocytes, TSH alone does not induce cell growth. Recently, it has been demonstrated that acute stimulation by TSH of porcine thyrocytes leads to release an inositolphosphate glycan (IPG) described as a putative second messenger for various growth factors in different cell types. IPG isolated from porcine thyrocytes induces proliferation of fibroblasts EGFR T17 and porcine thyrocytes. In porcine thyrocytes we have confirmed that cell growth requires the presence of both TSH and insulin. This effect is reproduced by 8-bromo cyclic AMP suggesting a mediation by intracellular cyclic AMP. Cooperative effects between 8-bromo cyclic AMP and IPG have also been evidenced and are in favour of a crosstalk between distinct signalling pathways.

Mots clés

3T3 Cells, Animals, Cell Division, Cells, Cultured, Cyclic AMP, metabolism, Glycosylphosphatidylinositols, metabolism, Inositol Phosphates, metabolism, Mice, Polysaccharides, metabolism, Rats, Signal Transduction, Swine, Thyroid Gland, cytology, Thyrotropin, physiology

Référence

Biochimie. 1998 Dec;80(12):1063-7