Genetic and transcriptomic analyses provide new insights on the early antiviral response to VHSV in resistant and susceptible rainbow trout.

Fiche publication

Date publication

juin 2018

Journal

BMC genomics

Auteurs

Membres identifiés du Cancéropôle Est :
Dr VERRIER Eloi

Tous les auteurs :
Verrier ER, Genet C, Laloë D, Jaffrezic F, Rau A, Esquerre D, Dechamp N, Ciobotaru C, Hervet C, Krieg F, Jouneau L, Klopp C, Quillet E, Boudinot P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/29921219

Résumé

The viral hemorrhagic septicemia virus (VHSV) is a major threat for salmonid farming and for wild fish populations worldwide. Previous studies have highlighted the importance of innate factors regulated by a major quantitative trait locus (QTL) for the natural resistance to waterborne VHSV infection in rainbow trout. The aim of this study was to analyze the early transcriptomic response to VHSV inoculation in cell lines derived from previously described resistant and susceptible homozygous isogenic lines of rainbow trout to obtain insights into the molecular mechanisms responsible for the resistance to the viral infection.