Interactions of the antimalarial drug methylene blue with methemoglobin and heme targets in Plasmodium falciparum: a physico-biochemical study.

Date publication

août 2012

Journal

Antioxidants & redox signaling

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DAVIOUD-CHARVET Elisabeth , Dr ELHABIRI Mourad

Tous les auteurs :
Blank O, Davioud-Charvet E, Elhabiri M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/22256987

Résumé

Resistance of Plasmodium falciparum to drugs has led to renewed interest of redox-active methylene blue (MB) for which no resistance has been reported so far. Moreover, MB displays unique interactions with glutathione reductase (GR). However, the mechanisms of action/interaction with potential targets of MB are yet to be elucidated. Our physico-biochemical study on MB and relevant hematin-containing targets was performed under quasi-physiological conditions.

Mots clés

Animals, Antimalarials, chemistry, Dimerization, Glutathione Reductase, metabolism, Heme, chemistry, Humans, Hydrogen-Ion Concentration, Methemoglobin, chemistry, Methylene Blue, chemistry, Molecular Structure, NADP, metabolism, Oxidation-Reduction, Plasmodium falciparum, metabolism, Proteolysis

Référence

Antioxid. Redox Signal.. 2012 Aug 15;17(4):544-54