Cascade: a R package to study, predict and simulate the diffusion of a signal through a temporal gene network.

Date publication

février 2014

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BAHRAM Siamak , Dr VALLAT Laurent

Tous les auteurs :
Jung N, Bertrand F, Bahram S, Vallat L, Maumy-Bertrand M

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/24307703

Résumé

SUMMARY: Temporal gene interactions, in response to environmental stress, form a complex system that can be efficiently described using gene regulatory networks. They allow highlighting the more influential genes and spotting some targets for biological intervention experiments. Despite that many reverse engineering tools have been designed, the Cascade package is an integrated solution adding several new and original key features such as the ability to predict changes in gene expressions after a biological perturbation in the network and graphical outputs that allow monitoring the spread of a signal through the network. AVAILABILITY AND IMPLEMENTATION: The R package Cascade is available online at http://www-math.u-strasbg.fr/genpred/spip.php?rubrique4.

Référence

Bioinformatics. 2014 Feb 15;30(4):571-3