Chondrogenic induction of mesenchymal stromal/stem cells from Wharton's jelly embedded in alginate hydrogel and without added growth factor: an alternative stem cell source for cartilage tissue engineering.

Date publication

décembre 2015

Journal

Stem cell research & therapy

Auteurs

Membres identifiés du Cancéropôle Est :
Pr BENSOUSSAN Danièle , Dr REPPEL Loïc

Tous les auteurs :
Reppel L, Schiavi J, Charif N, Leger L, Yu H, Pinzano A, Henrionnet C, Stoltz JF, Bensoussan D, Huselstein C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26718750

Résumé

Due to their intrinsic properties, stem cells are promising tools for new developments in tissue engineering and particularly for cartilage tissue regeneration. Although mesenchymal stromal/stem cells from bone marrow (BM-MSC) have long been the most used stem cell source in cartilage tissue engineering, they have certain limits. Thanks to their properties such as low immunogenicity and particularly chondrogenic differentiation potential, mesenchymal stromal/stem cells from Wharton's jelly (WJ-MSC) promise to be an interesting source of MSC for cartilage tissue engineering.

Mots clés

Adult, Alginates, chemistry, Bone Marrow Cells, cytology, Cartilage, physiology, Cell Differentiation, Cell Survival, Cells, Cultured, Chondrogenesis, Collagen Type II, metabolism, Collagen Type X, metabolism, Core Binding Factor Alpha 1 Subunit, metabolism, Glucuronic Acid, chemistry, Hexuronic Acids, chemistry, Humans, Hydrogels, chemistry, Mesenchymal Stem Cell Transplantation, Mesenchymal Stromal Cells, cytology, Middle Aged, Phenotype, Regeneration, Tissue Engineering, Wharton Jelly, cytology

Référence

Stem Cell Res Ther. 2015 Dec;6:260