Image analysis of immune cell patterns in the human mammary gland during the menstrual cycle refines lymphocytic lobulitis.

Date publication

juillet 2017

Journal

Breast cancer research and treatment

Auteurs

Membres identifiés du Cancéropôle Est :
Pr WEMMERT Cédric

Tous les auteurs :
Schaadt NS, Alfonso JCL, Schönmeyer R, Grote A, Forestier G, Wemmert C, Krönke N, Stoeckelhuber M, Kreipe HH, Hatzikirou H, Feuerhake F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/28444535

Résumé

To improve microscopic evaluation of immune cells relevant in breast cancer oncoimmunology, we aim at distinguishing normal infiltration patterns from lymphocytic lobulitis by advanced image analysis. We consider potential immune cell variations due to the menstrual cycle and oral contraceptives in non-neoplastic mammary gland tissue.

Mots clés

Digital pathology, Hormonal fluctuations, Lymphocytic lobulitis, Menstrual cycle, Object-based image analysis, Oncoimmunology

Référence

Breast Cancer Res. Treat.. 2017 Jul;164(2):305-315