Radiation-induced CD8 T-lymphocyte Apoptosis as a Predictor of Breast Fibrosis After Radiotherapy: Results of the Prospective Multicenter French Trial.

Date publication

décembre 2015

Journal

EBioMedicine

Auteurs

Membres identifiés du Cancéropôle Est :
Pr NOEL Georges , Dr PEIGNAUX Karine

Tous les auteurs :
Azria D, Riou O, Castan F, Nguyen TD, Peignaux K, Lemanski C, Lagrange JL, Kirova Y, Lartigau E, Belkacemi Y, Bourgier C, Rivera S, Noël G, Clippe S, Mornex F, Hennequin C, Kramar A, Gourgou S, Pèlegrin A, Fenoglietto P, Ozsahin EM

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26844275

Résumé

Monocentric cohorts suggested that radiation-induced CD8 T-lymphocyte apoptosis (RILA) can predict late toxicity after curative intent radiotherapy (RT). We assessed the role of RILA as a predictor of breast fibrosis (bf +) after adjuvant breast RT in a prospective multicenter trial.

Mots clés

Adult, Aged, Aged, 80 and over, Apoptosis, radiation effects, Biomarkers, Tumor, Breast Neoplasms, complications, CD8-Positive T-Lymphocytes, immunology, Female, Fibrocystic Breast Disease, diagnosis, Fibrosis, Humans, Incidence, Middle Aged, Neoplasm Grading, Neoplasm Staging, Prognosis, Proportional Hazards Models, Radiotherapy, Adjuvant, adverse effects, Recurrence, Risk Factors

Référence

EBioMedicine. 2015 Dec;2(12):1965-73