Outcome and risk of recurrence in a large cohort of idiopathic longitudinally extensive transverse myelitis without AQP4/MOG antibodies.

Fiche publication

Date publication

avril 2020

Journal

Journal of neuroinflammation

Auteurs

Membres identifiés du Cancéropôle Est :
Pr DE SEZE Jérôme

Tous les auteurs :
Maillart E, Durand-Dubief F, Louapre C, Audoin B, Bourre B, Derache N, Ciron J, Collongues N, de Sèze J, Cohen M, Lebrun-Frenay C, Hadhoum N, Zéphir H, Deschamps R, Carra-Dallière C, Labauge P, Kerschen P, Montcuquet A, Wiertlewski S, Laplaud D, Runavot G, Vukusic S, Papeix C, Marignier R,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32326965

Résumé

Longitudinally extensive transverse myelitis (LETM) is classically related to aquaporin (AQP4)-antibodies (Ab) neuromyelitis optica spectrum disorders (NMOSD) or more recently to myelin oligodendrocyte glycoprotein (MOG)-Ab associated disease. However, some patients remain negative for any diagnosis, despite a large work-up including AQP4-Ab and MOG-Ab. Data about natural history, disability outcome, and treatment are limited in this group of patients. We aimed to (1) describe clinical, biological, and radiological features of double seronegative LETM patients; (2) assess the clinical course and identify prognostic factors; and (3) assess the risk of recurrence, according to maintenance immunosuppressive therapy.