Concomitant hemorrhagic syndrome and recurrent extensive arterial thrombosis in a patient with COVID-19 and acute promyelocytic leukemia.

Date publication

mai 2020

Journal

British journal of haematology

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BILGER Karin , Pr HERBRECHT Raoul , Pr MAUVIEUX Laurent , Dr GANTZER Justine

Tous les auteurs :
Baldacini M, Pop R, Sattler L, Mauvieux L, Bilger K, Gantzer J, Schneider F, Beaujeux R, Simand C, Herbrecht R

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32369614

Résumé

Acute promyelocytic leukaemia and COVID-19 are two conditions associated with severe coagulopathy. We present here the multiple haemostasis abnormalities observed in a patient with concomitant acute promyelocytic leukaemia and COVID-19. The clinical consequences were dramatic and led to the death of the patient. A 62-year old woman was admitted on April 13, 2020 for unexplained asthenia, dyspnoea, and uncontrolled epistaxis. Clinical examination revealed pallor, left periorbital ecchymosis due to a recent fall, intrabuccal haemorrhagic bullae, persistent epistaxis, and mild splenomegaly. Oxygen saturation was 96%. Chest computed tomography (CT) was consistent with moderate COVID-19 pneumonia (9 points on a 0-25 scale)(Pan, et al 2020). The qRT-PCR of a nasopharyngeal swab was positive for SARS-CoV2.

Référence

Br. J. Haematol.. 2020 May 5;: