Long non-coding RNA profiling links subgroup classification of endometrioid endometrial carcinomas with trithorax and polycomb complex aberrations.

Date publication

novembre 2015

Journal

Oncotarget

Auteurs

Membres identifiés du Cancéropôle Est :
Pr MALOUF Gabriel

Tous les auteurs :
Jiang Y, Malouf GG, Zhang J, Zheng X, Chen Y, Thompson EJ, Weinstein JN, Yuan Y, Spano JP, Broaddus R, Tannir NM, Khayat D, Lu KH, Su X

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26431491

Résumé

Integrative analysis of endometrioid endometrial carcinoma (EEC) using multiple platforms has distinguished four molecular subgroups. However, the landscape of expressed long non-coding RNAs (lncRNA) and their role in charting EEC subgroups and determining clinical aggressiveness remain largely unknown.

Mots clés

Carcinoma, Endometrioid, genetics, Cluster Analysis, Endometrial Neoplasms, genetics, Enhancer of Zeste Homolog 2 Protein, Estrogen Receptor alpha, genetics, Female, Gene Expression Profiling, methods, Gene Expression Regulation, Neoplastic, Histone-Lysine N-Methyltransferase, genetics, Humans, Kaplan-Meier Estimate, Mutation, Myeloid-Lymphoid Leukemia Protein, genetics, Polycomb Repressive Complex 1, genetics, Polycomb Repressive Complex 2, genetics, Polycomb-Group Proteins, genetics, RNA, Long Noncoding, classification, Receptors, Progesterone, genetics, Signal Transduction, genetics, beta Catenin, genetics

Référence

Oncotarget. 2015 Nov 24;6(37):39865-76