Nanoparticle Mediated Tumor Vascular Disruption: A Novel Strategy in Radiation Therapy.

Date publication

novembre 2015

Journal

Nano letters

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DETAPPE Alexandre

Tous les auteurs :
Kunjachan S, Detappe A, Kumar R, Ireland T, Cameron L, Biancur DE, Motto-Ros V, Sancey L, Sridhar S, Makrigiorgos GM, Berbeco RI

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26418302

Résumé

More than 50% of all cancer patients receive radiation therapy. The clinical delivery of curative radiation dose is strictly restricted by the proximal healthy tissues. We propose a dual-targeting strategy using vessel-targeted-radiosensitizing gold nanoparticles and conformal-image guided radiation therapy to specifically amplify damage in the tumor neoendothelium. The resulting tumor vascular disruption substantially improved the therapeutic outcome and subsidized the radiation/nanoparticle toxicity, extending its utility to intransigent or nonresectable tumors that barely respond to standard therapies.

Mots clés

Gold nanoparticles, endothelial radiation damage, image-guided radiation therapy, tumor vascular disruption

Référence

Nano Lett.. 2015 Nov 11;15(11):7488-96