Heat shock and HSP70 regulate 5-FU-mediated caspase-1 activation in myeloid-derived suppressor cells and tumor growth in mice.

Date publication

mai 2020

Journal

Journal for immunotherapy of cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GARRIDO Carmen , Pr GHIRINGHELLI François , Dr REBE Cédric , Dr CHALMIN Fanny , Dr LIMAGNE Emeric , Dr DERANGERE Valentin

Tous les auteurs :
Pilot T, Fratti A, Thinselin C, Perrichet A, Demontoux L, Limagne E, Derangère V, Ilie A, Ndiaye M, Jacquin E, Garrido C, Ghiringhelli F, Chalmin F, Rébé C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32385145

Résumé

We have previously shown that 5-fluorouracil (5-FU) selectively kills myeloid-derived suppressor cells (MDSCs) and activates NLRP3 (NOD-leucine rich repeat and pyrin containing protein 3) inflammasome. NLRP3 activation leads to caspase-1 activation and production of IL-1β, which in turn favors secondary tumor growth. We decided to explore the effects of either a heat shock (HS) or the deficiency in heat shock protein (HSP) 70, previously shown to respectively inhibit or increase NLRP3 inflammasome activation in macrophages.

Mots clés

cytokines, immunity, cellular, immunomodulation, inflammation, inflammation mediators

Référence

J Immunother Cancer. 2020 May;8(1):