Expression of angiopoietin-like 4 fibrinogen-like domain (cANGPTL4) increases risk of brain metastases in women with breast cancer.

Date publication

mai 2020

Journal

Oncotarget

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FEUGEAS Jean-Paul

Tous les auteurs :
Dao T, Gapihan G, Leboeuf C, Hamdan D, Feugeas JP, Boudabous H, Zelek L, Miquel C, Tran T, Monnot C, Germain S, Janin A, Bousquet G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32405335

Résumé

Brain metastases challenge daily clinical practice, and the mechanisms by which cancer cells cross the blood-brain barrier remain largely undeciphered. Angiopoietin-like 4 (ANGPTL4) proteolytic fragments have controversial biological effects on endothelium permeability. Here, we studied the link between ANGPTL4 and the risk of brain metastasis in cancer patients.

Mots clés

blood-brain barrier, brain metastases, breast cancer, cANGPTL4, vascular permeability

Référence

Oncotarget. 2020 May 5;11(18):1590-1602