Somatic profile in lung cancers is associated to reproductive factors in never-smokers women: Results from the IFCT-1002 BioCAST study.

Date publication

janvier 2020

Journal

Respiratory medicine and research

Auteurs

Membres identifiés du Cancéropôle Est :
Dr COUDERT Bruno , Dr FOUCHER Pascal

Tous les auteurs :
Fontaine-Delaruelle C, Mazières J, Cadranel J, Mastroianni B, Dubos-Arvis C, Dumont P, Monnet I, Pichon E, Locatelli-Sanchez M, Dixmier A, Coudert B, Fraboulet S, Foucher P, Dansin E, Baize N, Vincent M, Missy P, Morin F, Moro-Sibilot D, Couraud S,

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32416585

Résumé

Lung cancer in women is on the rise, with a higher proportion occurring in lifelong never-smokers. Lung cancer in never-smokers (LCINS) exhibits a high frequency of driver oncogene alterations. In this study, we aimed to investigate whether exposure to reproductive factors in women with LCINS may modulate the molecular pattern.

Mots clés

Female hormonal factors, Lung cancer, Never-smoker, Oncogenic drivers

Référence

Respir Med Res. 2020 Jan 31;77:58-66