Design of the DRAGET Study: a multicentre controlled diagnostic study to assess the detection of acute rejection in patients with heart transplant by means of T2 quantification with MRI in comparison to myocardial biopsies.

Date publication

octobre 2015

Journal

BMJ open

Auteurs

Membres identifiés du Cancéropôle Est :
Pr FELBLINGER Jacques

Tous les auteurs :
Bonnemains L, Cherifi A, Girerd N, Odille F, Felblinger J

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/26515686

Résumé

Patients with heart transplant are screened for silent graft rejection by recurrent endomyocardial biopsies. MRI can detect the presence of oedema non-invasively by quantitatively measuring changes of the transverse relaxation time T2 in the myocardium. Several monocentric studies have shown that T2 quantification could help detect graft rejection in a less invasive way. DRAGET is a national multicentre diagnostic study designed to prove that T2 quantification by MRI can detect graft rejection.

Mots clés

Adolescent, Adult, Biopsy, Edema, Graft Rejection, diagnosis, Heart, Heart Transplantation, Humans, Magnetic Resonance Imaging, methods, Myocardium, pathology, Prognosis

Référence

BMJ Open. 2015 Oct 29;5(10):e008963