Fiche publication
Date publication
mai 2020
Journal
Angewandte Chemie (International ed. in English)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr SCHAAF Pierre
,
Dr SCHMUTZ Marc
Tous les auteurs :
Jennifer RF, Criado-Gonzalez M, Chaumont A, Carvalho A, Blanck C, Schmutz M, Boulmedais F, Schaaf P, Jierry L
Lien Pubmed
Résumé
Autocatalysis and self-assembly are key processes in developmental biology and are involved in the emergence of life. In the last decade both features were extensively investigated by chemists with the final goal to design synthetic living systems. Herein, we describe the autonomous growth of a self-assembled soft material, i.e. a supramolecular hydrogel, able to sustain its own formation through an autocatalytic mechanism not based on any template effect and emerging from a peptide (hydrogelator) self-assembly. A domino sequence of events starts from an enzymatically triggered peptide generation followed by their self-assembly into catalytic nanofibers inducing and amplifying their production over time, resulting in a 3D hydrogel network. A cascade is initiated by traces (10-18 M) of a trigger enzyme which can be localized allowing for a spatial resolution of this autocatalytic buildup, a sine qua none condition to fulfil on the route toward further cell mimic designs.
Mots clés
Autocatalysis * Peptide Self-assembly * Supramolecular Chemistry * Hydrogels * Surface Chemistry
Référence
Angew. Chem. Int. Ed. Engl.. 2020 May 28;:
