Glucocorticoids impair HDL-mediated cholesterol efflux besides increased HDL cholesterol concentration - a proof of concept.

Date publication

juin 2020

Journal

European journal of endocrinology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr VERGES Bruno , Dr PAIS DE BARROS Jean-Paul , Pr MASSON David

Tous les auteurs :
Bouillet B, Gautier T, Denimal D, Samson M, Masson D, Pais de Barros JP, Maquart G, Xolin M, Grosfeld A, Dalle H, Vergès B, Moldes M, Fève B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32570209

Résumé

Glucocorticoids (GC) are associated with increased cardiovascular morbidity despite increased HDL-C concentration. HDL-mediated cholesterol efflux, a major anti-atherogenic property of HDL particles, is negatively associated with CVD risk. We aimed to determine whether HDL-mediated cholesterol efflux was influenced by GC.

Référence

Eur. J. Endocrinol.. 2020 Jun 1;: