A subset of activated fibroblasts is associated with distant relapse in early luminal breast cancer.

Date publication

juillet 2020

Journal

Breast cancer research : BCR

Auteurs

Membres identifiés du Cancéropôle Est :
Dr LADOIRE Sylvain

Tous les auteurs :
Bonneau C, Eliès A, Kieffer Y, Bourachot B, Ladoire S, Pelon F, Hequet D, Guinebretière JM, Blanchet C, Vincent-Salomon A, Rouzier R, Mechta-Grigoriou F

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32665033

Résumé

Early luminal breast cancer (BC) represents 70% of newly diagnosed BC cases. Among them, small (under 2 cm) BC without lymph node metastasis (classified as T1N0) have been rarely studied, as their prognosis is generally favorable. Nevertheless, up to 5% of luminal T1N0 BC patients relapse with distant metastases that ultimately prove fatal. The aim of our work was to identify the mechanisms involved in metastatic recurrence in these patients.

Mots clés

CDH11, Cadherin 11, Cancer-associated fibroblasts, Luminal breast cancer, Metastases, Stroma, TILs, Tumor infiltrating lymphocytes, Tumor micro-environment

Référence

Breast Cancer Res.. 2020 Jul 14;22(1):76