Excess soluble fms-like tyrosine kinase 1 correlates with endothelial dysfunction and organ failure in critically ill COVID-19 patients.

Date publication

juillet 2020

Journal

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

Auteurs

Membres identifiés du Cancéropôle Est :
Pr NGUYEN Philippe

Tous les auteurs :
Dupont V, Kanagaratnam L, Goury A, Poitevin G, Bard M, Julien G, Bonnivard M, Champenois V, Noel V, Mourvillier B, Nguyen P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32672790

Résumé

Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of the vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here we demonstrate that sFlt-1 plasma levels correlate with respiratory symptoms severity, expression of endothelial dysfunction biomarker and incidence of organ failure in COVID-19 patients.

Mots clés

COVID-19, critical care, endothelial dysfunction, sFlt-1

Référence

Clin. Infect. Dis.. 2020 Jul 16;: