Fiche publication
Date publication
juillet 2020
Journal
Cancers
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GASMAN Stéphane
,
Dr VITALE Nicolas
,
Dr ORY Stéphane
Tous les auteurs :
Streit L, Brunaud L, Vitale N, Ory S, Gasman S
Lien Pubmed
Résumé
Neuroendocrine tumors (NETs) belong to a heterogeneous group of neoplasms arising from hormone secreting cells. These tumors are often associated with a dysfunction of their secretory activity. Neuroendocrine secretion occurs through calcium-regulated exocytosis, a process that is tightly controlled by Rho GTPases family members. In this review, we compiled the numerous mutations and modification of expression levels of Rho GTPases or their regulators (Rho guanine nucleotide-exchange factors and Rho GTPase-activating proteins) that have been identified in NETs. We discussed how they might regulate neuroendocrine secretion.
Mots clés
Rho GTPases, expression changes, hormone secretion, mutations, neuroendocrine tumors, vesicular trafficking
Référence
Cancers (Basel). 2020 Jul 10;12(7):
