Fiche publication
Date publication
août 2020
Journal
Respiratory research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr POLETTE Myriam
,
Dr DORMOY Valerian
Tous les auteurs :
Ancel J, Belgacemi R, Perotin JM, Diabasana Z, Dury S, Dewolf M, Bonnomet A, Lalun N, Birembaut P, Polette M, Deslée G, Dormoy V
Lien Pubmed
Résumé
The hedgehog (HH) pathway has been associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies and recent studies suggest that HH signalling could be altered in COPD. We therefore used minimally invasive endobronchial procedures to assess activation of the HH pathway including the main transcription factor, Gli2, and the ligand, Sonic HH (Shh).
Mots clés
Airway epithelial cells, Bronchoscopy, Chronic obstructive pulmonary disease, Hedgehog signalling pathway
Référence
Respir. Res.. 2020 Aug 7;21(1):207
