Megakaryocytes use in vivo podosome-like structures working collectively to penetrate the endothelial barrier of bone marrow sinusoids.

Fiche publication

Date publication

juillet 2020

Journal

Journal of thrombosis and haemostasis : JTH

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GACHET Christian

Tous les auteurs :
Eckly A, Scandola C, Oprescu A, Michel D, Rinckel JY, Proamer F, Hoffmann D, Receveur N, Léon C, Bear JE, Ghalloussi D, Harousseau G, Bergmeier W, Lanza F, Gaits-Iacovoni F, de la Salle H, Gachet C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32702204

Résumé

Blood platelets are anucleate cell fragments which prevent bleeding and minimize blood vessel injury. They are formed from the cytoplasm of megakaryocytes located in the bone marrow. For successful platelet production, megakaryocyte fragments must pass through the sinusoid endothelial barrier by a cell biology process unique to these giant cells as compared to erythrocytes and leukocytes. Currently, the mechanisms by which megakaryocytes interact and progress through the endothelial cells are not understood, resulting in a significant gap in our knowledge of platelet production.