Pubertal outcomes of children transplanted with allogeneic stem cells after myeloablative total body irradiation or busulfan: Influence of age and sex is confirmed, while a role of chronic graft-versus-host disease in delayed puberty onset is revealed.

Date publication

juillet 2020

Journal

Pediatric transplantation

Auteurs

Membres identifiés du Cancéropôle Est :
Dr POCHON Cécile

Tous les auteurs :
Weinhard S, Wiedemann A, Leheup B, Dalle JH, Lebon Labich B, Pochon C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32701220

Résumé

Myeloablative conditioning before allogeneic HSCT during childhood exposes to serious long-term complications, especially gonadal dysfunction. Pubertal issues are less described than other post-HSCT sequelae in childhood.

Mots clés

female sex, graft-versus-host disease, hematopoietic stem cell transplantation, myeloablative conditioning regimen, pubertal development

Référence

Pediatr Transplant. 2020 Jul 23;:e13773