Flavaglines as natural products targeting eIF4A and prohibitins: From traditional Chinese medicine to antiviral activity against coronaviruses.

Fiche publication

Date publication

juillet 2020

Journal

European journal of medicinal chemistry

Auteurs

Membres identifiés du Cancéropôle Est :
Dr BENKIRANE-JESSEL Nadia , Dr DESAUBRY Laurent , Dr NEBIGIL-DESAUBRY Canan

Tous les auteurs :
Nebigil CG, Moog C, Vagner S, Benkirane-Jessel N, Smith DR, Désaubry L

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32693294

Résumé

Flavaglines are cyclopenta[b]benzofurans found in plants of the genus Aglaia, several species of which are used in traditional Chinese medicine. These compounds target the initiation factor of translation eIF4A and the scaffold proteins prohibitins-1 and 2 (PHB1/2) to exert various pharmacological activities, including antiviral effects against several types of viruses, including coronaviruses. This review is focused on the antiviral effects of flavaglines and their therapeutic potential against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).