Death of an alcohol-dependent patient following intentional drug intoxication: implication of baclofen?

Date publication

janvier 2014

Auteurs

Membres identifiés du Cancéropôle Est :
Pr JOUZEAU Jean-Yves

Tous les auteurs :
Pape E, Roman E, Scala-Bertola J, Thivilier C, Javot L, Saint-Marcoux F, Jouzeau JY, Gambier N

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/25300747

Résumé

Used in the treatment of spasticity at low doses, baclofen is also prescribed off-label at high doses for the treatment of alcohol dependence. Several cases of baclofen intoxication have been reported, but only 1 case deals with the treatment of alcohol dependence. Thus, we report the first death in the context of baclofen off-label use of an alcohol-dependent patient with a high blood baclofen concentration after intentional drug intoxication. The safety profile of baclofen in the treatment of alcohol dependence is reviewed and discussed, underlining the obligatory caution that may support any prescription of high doses of baclofen in this off-label indication and especially in patients with concomitant psychiatric disorders.

Référence

Eur Addict Res. 2014;20(6):300-4