Single-nucleotide polymorphism rs1761667 in the gene is associated with orosensory perception of a fatty acid in obese and normal-weight Moroccan subjects.

Fiche publication

Date publication

janvier 2020

Journal

Journal of nutritional science

Auteurs

Membres identifiés du Cancéropôle Est :
Pr KAHN Naim , Dr HICHAMI Aziz

Tous les auteurs :
Bajit H, Ait Si Mohammed O, Guennoun Y, Benaich S, Bouaiti E, Belghiti H, Mrabet M, Elfahime EM, El Haloui NE, Saeid N, El Kari K, Hichami A, Khan NA, Benkirane H, Aguenaou H

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32685140

Résumé

Obese subjects have shown a preference for dietary lipids. A recent collection of evidence has proposed that a variant in the gene plays a significant role in this pathway. We assessed the association between the orosensory detection of a long-chain fatty acid, i.e. oleic acid (OA), and genetic polymorphism of the lipid taste sensor CD36 in obese and normal-weight subjects. Adult participants were recruited in the fasting condition. They were invited to fat taste perception sessions, using emulsions containing OA and according to the three-alternative forced-choice (3-AFC) method. Genomic DNA was used to determine the polymorphism (SNP rs 1761667) of the gene. Obese ( 50; BMI 34⋅97 (sd 4⋅02) kg/m) exhibited a significantly higher oral detection threshold for OA (3⋅056 (sd 3⋅53) mmol/l) than did the normal-weight ( 50; BMI 22⋅16 (sd 1⋅81) kg/m) participants (1⋅20 (sd 3⋅23) mmol/l; = 0⋅007). There was a positive correlation between OA detection thresholds and BMI in all subjects; evenly with body fat percentage (BF%). AA genotype was more frequent in the obese group than normal-weight group. OA detection thresholds were much higher for AA and AG genotypes in obese subjects compared with normal-weight participants. Higher oral detection thresholds for fatty acid taste are related to BMI, BF% and not always to genotype.