Oscillatory potentials abnormalities in regular cannabis users: Amacrine cells dysfunction as a marker of central dopaminergic modulation.

Fiche publication

Date publication

août 2020

Journal

Progress in neuro-psychopharmacology & biological psychiatry

Auteurs

Membres identifiés du Cancéropôle Est :
Pr ALBUISSON Eliane

Tous les auteurs :
Polli L, Schwan R, Albuisson E, Malbos L, Angioi-Duprez K, Laprevote V, Schwitzer T

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32860840

Résumé

Cannabis is a neuromodulating substance that acts on central synaptic transmission. Regular cannabis use induces a decreased capacity for dopamine synthesis in the brain. The retina is considered an easy means of investigating dysfunctions of synaptic transmission in the brain. We have previously studied the impact of regular cannabis use on retinal function. Using the N95 wave of the pattern electroretinogram, we found a 6 ms-delayed ganglion cells response. Using the b-wave of the photopic flash electroretinogram, we found a 1 ms-delayed bipolar cells response. Here, we investigated amacrine cells function because these cells are located between the bipolar cells and the ganglion cells and contribute to amplifying the signal between these two layers of the retina. We tested the effect of regular cannabis use on these retinal dopaminergic cells. We assessed the role of these cells in amplifying the delay observed previously.