Atypical hemolytic and uremic syndrome due to C3 mutation in pancreatic islet transplantation: a case report.

Date publication

septembre 2020

Journal

BMC nephrology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CHENARD Marie-Pierre , Dr BALTZINGER Philippe

Tous les auteurs :
Bahougne T, Olagne J, Munch M, Braun-Parvez L, Chenard MP, Frémeaux-Bacchi V, Caillard S, Baltzinger P, Greget M, Kessler L, Moulin B

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/32950058

Résumé

We here report on the first observation of a C3 mutation that is related to atypical hemolytic and uremic syndrome (aHUS), which occurred in a pancreatic islet transplant patient. Immunosuppressive treatments, such as calcineurin inhibitors, have been linked to undesirable effects like nephrotoxicity.

Mots clés

Atypical hemolytic and uremic syndrome, Case report, Complement C3, Islets of Langerhans transplantation

Référence

BMC Nephrol. 2020 Sep 19;21(1):405