Fiche publication
Date publication
septembre 2020
Journal
Natural product research
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WAGNER Alain
,
Dr GARNIER Delphine
,
Dr CHAUBET Guilhem
Tous les auteurs :
Toussi Matchi JL, Tchamo Noungoue D, Kuhn I, Boissier J, Tchouankeu JC, Nothisen M, Chaubet G, Garnier D, Ursuegui S, Ngouela SA, Wagner A
Lien Pubmed
Résumé
A new alkaloid, manniindole , together with four known compounds: aristolactam AII , aristolactam BII , piperolactam D and polycarpol were isolated from the crude extract EtOH-HO (8:2) of the roots of by chromatographic separation. The structure elucidation was performed on the basis of a spectroscopic analysis (IR, HRESI MS, 1D and 2D NMR) as well as a comparison of their spectral data with those reported in the literature. For the first time, the crude extract and those isolated compounds were evaluated for their anti-schistosomal activity against and for cytotoxicity activity against Huh7 and A549 cells. Furthermore, they were also tested on the recent characterized NAD catabolizing enzyme (NACE) for their impact on this enzyme which is localized on the outer surface of the adult parasite. Compound displayed quite good worm killing capability, while showed significant inhibition of NACE.
Mots clés
Anonidium mannii , Annonaceae, anti-schistosomal activity, cytotoxicity, enzymatic activity (SmNACE), indole alkaloid, phytochemical and biological investigation
Référence
Nat. Prod. Res.. 2020 Sep 28;:1-9
