Fiche publication
Date publication
septembre 2020
Journal
ACS applied materials & interfaces
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BEGIN-COLIN Sylvie
,
Dr MERTZ Damien
Tous les auteurs :
Kesse X, Adam A, Begin-Colin S, Mertz D, Larquet E, Gacoin T, Maurin I, Vichery C, Nedelec JM
Lien Pubmed
Résumé
The past decades have seen the development of new bone cancer therapies, triggered by the discovery of new biomaterials. When the tumoral area is small and accessible, the common clinical treatment implies the tumor mass removal followed by bone reconstruction or consolidation with a bioceramic or a metallic scaffold. Even though the treatment also involves chemotherapy or radiotherapy, resurgence of cancer cells remains possible. We have thus designed a new kind of heterostructured nanobiomaterial, composed of SiO-CaO bioactive glass as shell and superparamagnetic γ-FeO iron oxide as core in order to combine the benefits of bone repair thanks to the glass bioactivity and of cancer cells destruction through magnetic hyperthermia (MH). These multifunctional core-shell nanoparticles (NPs) have been obtained using a two-stage procedure, involving the coprecipitation of 11 nm sized iron oxide NPs followed by their encapsulation inside a bioactive glass shell by sol-gel chemistry. The as-produced spherical multicore-shell NPs show a narrow size distribution of 73 ± 7 nm. Magnetothermal loss measurements by calorimetry under an alternating magnetic field and in vitro bioactivity assessment performed in SBF (Simulated Body Fluid) showed that these heterostructures exhibit a good heating capacity and a fast mineralization process (hydroxyapatite forming ability). In addition, their in vitro cytocompatibility, evaluated in the presence of Human Mesenchymal Stem Cells (h-MSCs) during 3 and 7 days, has been demonstrated. These first findings suggest that γ-FeO@SiO-CaO heterostructures are a promising biomaterial to fill bone defects resulting from bone tumors resection, as they have the ability to both repair bone tissue and to act as thermo-seeds for cancer therapy.
Référence
ACS Appl Mater Interfaces. 2020 Sep 29;:
