Fiche publication
Date publication
janvier 2015
Journal
Chemistry, an Asian journal
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BEGIN-COLIN Sylvie
,
Dr BIANCO Alberto
Tous les auteurs :
Chechetka SA, Pichon B, Zhang M, Yudasaka M, Bégin-Colin S, Bianco A, Miyako E
Lien Pubmed
Résumé
Multifunctional carbon nanohorn (CNH) complexes were synthesized using oxidized CNH, magnetite (MAG) nanoparticles, and polyethyleneimine (PEI). The ferromagnetic MAG nanoparticles were loaded onto CNH (MAG-CNH) using iron(II) acetate and subsequent heat treatment. Chemical functionalization of the MAG-CNH complexes with PEI improved their water-dispersibility and allowed further conjugation with a fluorophore. The application of an external magnetic field significantly intensified the targeted vectorization of CNH complexes into human cervical cancer (HeLa) cells. Following cell uptake, laser irradiation of the cells showed a significant enhancement in the photothermal effects of CNHs leading to cell death. We have confirmed that the photothermal properties and ferromagnetic characteristics of CNH complexes show efficient cell elimination. The present study is an essential step toward the development of an innovative cancer therapy and a highly sensitive detection of cancer cells at the single-cell level.
Mots clés
Antineoplastic Agents, chemistry, Carbon, chemistry, Cell Survival, drug effects, Fluorescent Dyes, chemistry, HeLa Cells, Humans, Lasers, Magnetite Nanoparticles, chemistry, Nanostructures, chemistry, Polyethyleneimine, chemistry
Référence
Chem Asian J. 2015 Jan;10(1):160-5
