Enhancement of anti-inflammatory drug activity by multivalent adamantane-based dendrons.

Date publication

août 2012

Journal

Biomaterials

Auteurs

Membres identifiés du Cancéropôle Est :
Dr DUMORTIER Hélène , Dr BIANCO Alberto

Tous les auteurs :
Lamanna G, Russier J, Dumortier H, Bianco A

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/22560196

Résumé

We have developed a straightforward method to prepare 1(st) and 2(nd) generation adamantane-based dendrons, previously called HYDRAmers, bearing at the periphery the anti-inflammatory drug, ibuprofen. The multivalency effect on the drug activity was studied, demonstrating that our multivalent ibuprofen-dendron conjugates exert an enhanced anti-inflammatory activity compared to free ibuprofen, in vitro. These results provide insights into the effect of HYDRAmer multivalency on biological interactions for therapeutic applications.

Mots clés

Animals, Anti-Inflammatory Agents, administration & dosage, Cell Line, Cell Survival, drug effects, Dendrimers, administration & dosage, Drug Synergism, Ibuprofen, administration & dosage, Macrophages, cytology, Mice

Référence

Biomaterials. 2012 Aug;33(22):5610-7