Fiche publication
Date publication
février 2011
Journal
Journal of peptide science : an official publication of the European Peptide Society
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DUMORTIER Hélène
,
Dr BIANCO Alberto
Tous les auteurs :
Gaillard C, Duval M, Dumortier H, Bianco A
Lien Pubmed
Résumé
Carbon nanotubes functionalized with cell adhesion peptides can be considered as novel, promising candidates for the development of advanced drug delivery systems or for designing new generation of self-assembling nerve 'bridges'. An important step toward the integration of these types of conjugates in living bodies is the assessment of their impact on the immune system. In this direction, an integrin-derived peptide has been covalently conjugated to carbon nanotubes. Following intraperitoneal administration, peptide-carbon nanotubes do not trigger an anti-peptide antibody production. Demonstration of the immune neutrality of peptide-carbon nanotubes reinforces their potential use as substrates for neuronal regeneration in vivo.
Mots clés
Enzyme-Linked Immunosorbent Assay, Nanotubes, Carbon, chemistry, Peptides, chemistry
Référence
J. Pept. Sci.. 2011 Feb;17(2):139-42
