Fiche publication
Date publication
novembre 2020
Journal
Journal of biophotonics
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GOBINET Cyril
,
Pr PIOT Olivier
,
Pr SOCKALINGUM Ganesh
Tous les auteurs :
Derruau S, Gobinet C, Untereiner V, Sockalingum GD, Nassif A, Viguier M, Piot O, Lorimier S
Lien Pubmed
Résumé
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease which can lead to a prolonged physical disability. HS diagnosis is exclusively clinical with the absence of biomarkers. Our study aims at assessing the HS-diagnostic potential of infrared spectroscopy from saliva, as a biofluid reflecting the body's pathophysiological state. Infrared spectra from 127 patients (57 HS and 70 non-HS) were processed by multivariate methods: principal component analysis coupled with Kruskal-Wallis or Mann-Whitney tests to identify discriminant spectral wavenumbers and linear discriminant analysis to evaluate the performances of HS-diagnostic approach. Infrared features, mainly in the 1300-1600 cm region, were identified as discriminant for HS and prediction models revealed diagnostic performances about of 80%. Tobacco and obesity, two main HS risk factors, do not seem to alter the infrared diagnosis. This pilot study shows the potential of salivary "liquid biopsy" associated to vibrational spectroscopy to develop a personalized medical approach for HS patients' management. This article is protected by copyright. All rights reserved.
Mots clés
Fourier Transform Infrared Spectroscopy, Hidradenitis suppurativa, PCA-LDA, diagnostic biosignatures, saliva
Référence
J Biophotonics. 2020 Nov 24;:
