Investigation of the prognostic value of CD4 T cell subsets expanded from tumor-infiltrating lymphocytes of colorectal cancer liver metastases.

Date publication

novembre 2020

Journal

Journal for immunotherapy of cancer

Auteurs

Membres identifiés du Cancéropôle Est :
Pr ADOTEVI Olivier , Pr BORG Christophe , Dr GODET Yann , Mme BOUARD Adeline , Dr DESCHAMPS Marina , Pr HEYD Bruno , Dr LOYON Romain , Dr KROEMER Marie

Tous les auteurs :
Kroemer M, Turco C, Spehner L, Viot J, Idirène I, Bouard A, Renaude E, Deschamps M, Godet Y, Adotévi O, Limat S, Heyd B, Jary M, Loyon R, Borg C

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33229508

Résumé

The positive role of CD8+ tumor-infiltrating lymphocytes (TIL) in patients with colorectal cancer (CRC) has been well described but the prognostic value of CD4 T cell subsets remained to be investigated. In this study, we expanded TIL from surgically resected liver metastases of patients with CRC and characterized the phenotype and the prognostic value of expanded-CD4 T cells.

Mots clés

CD4-positive t-lymphocytes, adaptive immunity, biomarkers, gastrointestinal neoplasms, lymphocytes, tumor, tumor-infiltrating

Référence

J Immunother Cancer. 2020 Nov;8(2):