Fiche publication
Date publication
janvier 2020
Journal
ACS chemical neuroscience
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BIANCO Alberto
Tous les auteurs :
Dinesh B, Medelin M, Scaini D, Lareno Faccini F, Quici F, Ballerini L, Bianco A
Lien Pubmed
Résumé
Peptides constituted of backbone homologated α-amino acids combined with carbon materials offer interesting possibilities in the modulation of cellular functions. In this work, we have prepared diphenylalanine β- and γ-peptides and conjugated them to carbon nanotubes (CNTs). These hybrids were able to self-assemble into fibrillar dendritic structures enabling the growth of primary hippocampal cells and the modulation of their neuronal functions. In particular, following the deposition of the different nanomaterials on glass substrates, we have evaluated their effects on circuit function and geometry. The geometrical restrictions due to CNT nucleated nodes allowed growth of neuronal networks with control over network geometry, and exploring its functional impact. In diverse applications from basic neuroscience, the presence of CNT nodes may be exploited in brain interfaces able to convey highly localized electrical stimuli.
Mots clés
carbon nanotubes, diphenylalanine, hippocampal neurons, patch-clamp, peptides, self-assembly
Référence
ACS Chem Neurosci. 2020 01 15;11(2):162-172
