Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation.

Fiche publication

Date publication

décembre 2020

Journal

Brain, behavior, and immunity

Auteurs

Membres identifiés du Cancéropôle Est :
Pr POISBEAU Pierrick

Tous les auteurs :
Gazzo G, Melchior M, Caussaint A, Gieré C, Lelièvre V, Poisbeau P

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33316378

Résumé

Early life stress is known to affect the development of the nervous system and its function at a later age. It increases the risk to develop psychiatric disorders as well as chronic pain and its associated affective comorbidities across the lifespan. GABAergic inhibition is important for the regulation of central function and related behaviors, including nociception, anxiety or social interactions, and requires low intracellular chloride levels. Of particular interest, the oxytocinergic (OTergic) system exerts potent anxiolytic, analgesic and pro-social properties and is known to be involved in the regulation of chloride homeostasis and to be impaired following early life stress.