Total gastrectomy for severe proton pump inhibitor-induced hypomagnesemia in a MEN1/Zollinger Ellison syndrome patient.

Date publication

décembre 2020

Journal

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

Auteurs

Membres identifiés du Cancéropôle Est :
Pr CADIOT Guillaume

Tous les auteurs :
Perrier M, Delemer B, Deguelte S, Legros V, Brixi H, Kianmanesh R, Cadiot G

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33309626

Résumé

We report here the first case of life-threatening hypomagnesemia in a Zollinger-Ellison syndrome patient with multiple endocrine neoplasia type 1 (MEN1) syndrome. The severe symptomatic hypomagnesemia proved to be due to proton pump inhibitors (PPIs), but withdrawal of PPIs led to early severe peptic complications despite a substitution by histamine H2-receptor antagonist therapy. Simultaneous management of life-threatening hypomagnesemia, severe gastric acid hypersecretion and MEN1-associated gastrinomas was complex. A total gastrectomy was performed in order to definitely preclude the use of PPIs in this frail patient who was not eligible for curative pancreatoduodenal resection.

Mots clés

Gastrinoma, Hypomagnesemia, Multiple endocrine neoplasia type 1 syndrome, Proton pump inhibitor, Total gastrectomy, Zollinger-Ellison syndrome

Référence

Pancreatology. 2020 Dec 7;: