Endothelium-independent vasorelaxant effect of Asphodelus tenuifolius Cav. via inhibition of myosin light chain kinase activity in the porcine coronary artery.

Date publication

décembre 2020

Journal

Journal of ethnopharmacology

Auteurs

Membres identifiés du Cancéropôle Est :
Pr SCHINI-KERTH Valérie

Tous les auteurs :
Younis W, Alamgeer,Schini-Kerth VB, Junior AG, Nocchi SR, Silva DB, Roberts RE

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33326818

Résumé

Asphodelus tenuifolius Cav. (Asphodelaceae), a wild, terrestrial, annual stemless herb, is widely used in traditional medicine for the treatment of hypertension, diabetes, atherosclerosis and circulatory problems. A previous research study from our laboratory revealed that A. tenuifolius has beneficial effects in reducing blood pressure and improves aortic endothelial dysfunction in chronically glucose fed rats. Despite the fact that A. tenuifolius reduces blood pressure and improves endothelial function in vivo, there are no detailed studies about its possible mechanism of action.

Mots clés

Alpha,beta-MeATP (PubChem CID: 91557), Asphodelus tenuifolius, Bayk8644 (PubChem CID: 2303), Bradykinin (PubChem CID: 439201), Dicloromethane (PubChem CID: 6344), Ethyl acetate (PubChem CID: 8857), Forskolin (PubChem CID: 47936), Ionomycin (PubChem CID: 6912226), Methanol (PubChem CID: 887), Myosin light chain kinase, Nifedipine (PubChem CID: 4485), ODQ (PubChem CID: 1456), Tetraethylammonium (PubChem CID: 5413), U46619 (PubChem CID: 5311493), Y27632 (PubChem CID: 448042), calcium influx, coronary artery, n-Butanol (PubChem CID: 263), n-Hexane (PubChem CID: 8058), vascular smooth muscle, vasodilatation

Référence

J Ethnopharmacol. 2020 Dec 13;:113693