Fiche publication


Date publication

décembre 2020

Journal

Expert opinion on therapeutic patents

Auteurs

Membres identifiés du Cancéropôle Est :
Dr GARRIDO Carmen , Pr LIRUSSI Frédéric


Tous les auteurs :
Hu S, Hui Z, Lirussi F, Garrido C, Ye XY, Xie T

Résumé

DNA-dependent protein kinase (DNA-PK) plays a crucial role in the repair of DSBs via non-homologous end joining (NHEJ). Several DNA-PK inhibitors are being investigated for potential anticancer treatment in clinical trials.

Mots clés

DNA damage response (DDR), DNA double strand breaks (DSBs), DNA-PK, cancer therapy, inhibitor, patent review

Référence

Expert Opin Ther Pat. 2020 Dec 21;: