The elastin peptide VGVAPG increases CD4 T-cell IL-4 production in patients with chronic obstructive pulmonary disease.

Date publication

janvier 2021

Journal

Respiratory research

Auteurs

Membres identifiés du Cancéropôle Est :
Pr ANTONICELLI Franck , Pr LE NAOUR Richard , Dr AUDONNET Sandra

Tous les auteurs :
Lemaire F, Audonnet S, Perotin JM, Gaudry P, Dury S, Ancel J, Lebargy F, Antonicelli F, Deslée G, Le Naour R

Lien Pubmed

https://www.ncbi.nlm.nih.gov/pubmed/33435988

Résumé

In chronic obstructive pulmonary disease (COPD), lung-infiltrating inflammatory cells secrete proteases and participate in elastin breakdown and genesis of elastin-derived peptides (EP). In the present study, we hypothesized that the pattern of T lymphocytes cytokine expression may be modulated by EP in COPD patients.

Mots clés

COPD, Cytokines, Elastin peptides, Flow cytometry, IL-4, T cells

Référence

Respir Res. 2021 Jan 13;22(1):14